CD44 regulates Wnt signaling at the level of LRP6
نویسندگان
چکیده
CD44 was recently identified as a positive feedback regulator of Wnt/β-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2015